Novel thiophene derivatives for the treatment of benign prostatic hyperplasia

Haripada Khatuya; Virginia L Pulito; Linda K Jolliffe; Xiaobing Li; William V Murray

doi:10.1016/s0960-894x(02)00347-5

Novel thiophene derivatives for the treatment of benign prostatic hyperplasia

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2145-8. doi: 10.1016/s0960-894x(02)00347-5.

Authors

Haripada Khatuya¹, Virginia L Pulito, Linda K Jolliffe, Xiaobing Li, William V Murray

Affiliation

¹ Johnson & Johnson Pharmaceutical Research and Development LLC, Drug Discovery Research, 1000 Route 202, PO Box 300, Raritan, NJ 08869, USA.

PMID: 12127524
DOI: 10.1016/s0960-894x(02)00347-5

Abstract

The syntheses and biological activities of a novel series of 2,4- and 2,5-disubstituted thiophenes are reported. These analogues have shown excellent affinity and selectivity against alpha(1)-adrenoreceptor subtypes.

MeSH terms

Adrenergic alpha-Antagonists / chemical synthesis
Adrenergic alpha-Antagonists / chemistry
Adrenergic alpha-Antagonists / pharmacology
Binding Sites
Humans
Male
Molecular Structure
Prostatic Hyperplasia / drug therapy*
Structure-Activity Relationship
Thiophenes / chemical synthesis*
Thiophenes / chemistry
Thiophenes / pharmacology*

Substances

Adrenergic alpha-Antagonists
Thiophenes